Curcumin Is Efective In Improving Folliculogenesis Profile And Oo-cytes Quality In Vitro In Ectopic Endometriosis Mouse (Mus muscu-lus) Models

Aulia Firmawati, Widjiati widjiati


Endometriosis is the presence of ectopic endometrial tissue, such as that outside the uter-ine cavity, which can cause chronic inflammatory reactions. Curcumin is one of traditional herbal med-icines that is widely used. Some experiments have managed to find a mechanism to treat an ectopic endometriosis through the mechanism of suppression of several cytokines such as TNF-alpha, NF-kB and COX-2, this study was an experimental laboratory study, with five treatments and six replications, using female mice (Mus musculus) that had reached puberty. The study consisted of three phases: the first phase was the microscopic examination of in vitro oocytes quality, and the second was histopatho-logical examination of folliculogenesis profile using Hematoxillin eosin staining, the results of this study showed significant difference between positive control group (P0) with treatment and negative control (KN) groups in folliculogenesis profile (p <0.05). Examination of in vitro oocytes quality showed sig-nificant difference between positive control group with treatment group and negative control group (p <0.05). Curcumin has several roles in cytokines modulation in ectopic endometriosis mouse models. Curcumin may reduce the occurrence of apoptosis of granulosa cells so that it may directly improve oocyte quality and folliculogenesis profile, in conclusion, curcumin effectively overcomes fertility prob-lems through the mechanism of cytokines modulation that plays a role in some cases of endometriosis such as: TNF-alpha, NF-kB and COX-2. Curcumin may improve folliculogenesis profile and in vitro oocytes quality.


ectopic endometriosis, curcumin, folliculogenesis profile, oocyte quality

Full Text:



Anwar, R. 2005. Morfologi dan Fungsi Ovarium. Subbagian Fertilitas dan Endokrinologi Reproduksi. Fakultas Kedokteran Unniversitas Padjajaran. Bandung.

Awwad J.T., RA Sayegh, XJ Tao. The SCID mouse: an experimental model for endometriosis. Human Reproduction. 1999; 14 (12) : 3107 – 11

Grummer R .2006. Animal models in en-dometriosis research; human re-production update vol 12, no 5 pp.641-649.

Hendarto H. 2007. Profil TNF-α, GDF-9 dan Hyaluronan Pada Gangguan Folikulogenesis Sebagai Gam-baran Penurunan Kualitas Oosit Pasien Infertil Dengan Endometri-osis. Disertasi. Program Pascasar-jana. Universitas Airlangga. Sura-baya.

Herliana Inna., Hendy Kendarto., Aulan-ni’am., dan M.S. Djati.2008. Profil GDF9 (Growth Differential Factor 9) dan Hubungannya dengan PGE2 (Prostalgaldin E2) dari Pasies En-dometriosis. Fakultas Matematika dan Ilmu Pengetahuan Alam. Uni-versitas Brawijaya. Malang.

Joe B, M Vijaykumar and RB Lokes.2004. Biological properties of curcumin-celluler and molecular mecha-nisms of action. Critical review in food science and nutrition, 44: 97-111.

Sharma R.A, Gescher A.J, Steward W.P. 2005. Curcumin the story so far, European Journal of cancer 41, 1955-1968.

Splitterj, G. A.,. H. Kirk., W. F. Enziea Mack., and C. A. Rawlings. 2004. Endometriosis in four irradiated rhesus monkeys. Veterinary Sci-ence Division and radiobiology Division, USAF School of Aero-space Mecdicine, Acrospace Med-ical Division, AFSC, United States Air Force Brooks Air Force Base.Tex.

Widjiati, B. S.Poemomo, E. M. Luqman, D. M. Endang dan M. Mafuchati. 2004. Penuntun Embriologi. Fakultas Kedokteran Hewan. Uni-versitas Airlangga. Surabaya.

Wieser F, Cohen M, and A Gaeddert.2007. Evolution of med-ical treatment for endometriosis: back to the roots. Human Repro-duction Update, Vol 13, No.5 pp487-499.



  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.